G0462–ἀνόσιος–anosios

and remembers that a law is not enacted to control a righteous man, but for the lawless and rebellious, the irreligious and sinful, the godless and profane--for those who strike their fathers or their mothers, for murderers,

ἀνοσίοις anosiois “for [the] unholy”

For men will be lovers of self, lovers of money, boastful, haughty, profane. They will be disobedient to parents, thankless, irreligious,

ἀνόσιοι, anosioi “unholy,”